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Abstract Introduction: Obstructive sleep apnea is characterized by a reduced airflow through the upper airways during sleep. Two forms of obstructive sleep apnea are described: the central form and the obstructive form. The obstructive form is related to many factors, such as the craniofacial morphology. Objective: To evaluate the correlation between the morphology of the cranial base, of the mandible and the maxilla, and obstructive sleep apnea severity. Methods: Eighty-four patients, mean age of 50.4 years old; 73 males and 11 females with obstructive sleep apnea were enrolled in the present study. Patients with high body mass index and comorbidities were excluded. Lateral cephalograms and polysomnography were collected for each patient to evaluate the correlation between craniofacial morphology and obstructive sleep apnea severity. A Spearman's rho correlation test between cephalometric measurements and obstructive sleep apnea indexes was computed. Statistical significance was set at p < 0.05. Results: Patients with a severe obstructive sleep apnea presented a reduction of sagittal growth of both effective mandibular length and cranio-basal length. The mandibular length was the only variable with a statistical correlation with apnea-hypopnea index. Vertical dimension showed a weak correlation with the severity of obstructive sleep apnea. No correlation with maxillary sagittal dimension was shown. Conclusion: Obstructive sleep apnea severity may be correlated to mandibular and cranial base growth. Facial vertical dimension had no correlation with obstructive sleep apnea severity.
Resumo Introdução: A apneia obstrutiva do sono é caracterizada por um fluxo de ar reduzido nas vias aéreas superiores durante o sono. Duas formas de apneia são descritas: a forma central e a forma obstrutiva. A forma obstrutiva tem sido relacionada a vários fatores, como a morfologia craniofacial. Objetivo: Avaliar a correlação entre a morfologia da base do crânio, da mandíbula e da maxila e a gravidade da apneia obstrutiva do sono. Método: Foram incluídos no presente estudo 84 pacientes com apneia obstrutiva do sono, com média de 50,4 anos; 73 homens e 11 mulheres. Pacientes com alto índice de massa corpórea e comorbidades foram excluídos. Foram coletados cefalogramas laterais e polissonografia para cada paciente para avaliar a correlação entre a morfologia craniofacial e a gravidade da apneia. Foi computado o coeficiente de correlação de postos de Spearman (rho) entre medidas cefalométricas e índices de apneia obstrutiva do sono. A significância estatística foi estabelecida em p < 0,05. Resultados: Pacientes com apneia obstrutiva do sono grave apresentaram redução do crescimento sagital do comprimento mandibular efetivo e do comprimento crânio-basal. O comprimento mandibular foi a única variável que apresentou correlação estatística com o índice de apneia-hipopneia. A dimensão vertical mostrou uma fraca correlação com a gravidade da apneia. Não foi demonstrada correlação com a dimensão maxilar sagital. Conclusão: A gravidade da apneia obstrutiva do sono pode estar correlacionada ao crescimento da base mandibular e craniana. A dimensão facial vertical não apresentou correlação com a gravidade da apneia.
Subject(s)
Humans , Male , Female , Sleep Apnea, Obstructive/diagnostic imaging , Cephalometry/methods , Polysomnography , Mandible/diagnostic imaging , Maxilla/diagnostic imaging , Middle AgedABSTRACT
In order to realize the rapid and non-destructive detection of SO_2 content in sulphur-fumigated Achyranthis Bidentatae Radix, this paper first prepared the sulphur-fumigated Achyranthis Bidentatae Radix samples with the usage amount of sulphur being 0, 2.5%, and 5% of the mass of Achyranthis Bidentatae Radix pieces. The SO_2 content in different batches of sulphur-fumigated Achyranthis Bidentatae Radix was determined using the method in Chinese Pharmacopoeia, followed by the acquisition of their hyperspectral data within both visible-near infrared(435-1 042 nm) and short-wave infrared(898-1 751 nm) regions by hyperspectral imaging. Meanwhile, the first derivative, AUTO, multiplicative scatter correction, Savitzky-Golay(SG) smoothing, and standard normal variable transformation algorithms were used to pre-process the original hyperspectral data, which were then subjected to characteristic band extraction based on competitive adaptive reweighted sampling(CARS) and the partial least square regression analysis for building a quantitative model of SO_2 content in sulphur-fumigated Achyranthis Bidentatae Radix. It was found that the accuracy of the quantitative model built depending on the visible-near infrared spectra was high, with the determination coefficient of prediction set(R■) reaching 0.900 1. The established quantitative model has enabled the rapid and non-destructive detection of SO_2 content in sulphur-fumigated Achyranthis Bidentatae Radix, which can serve as an effective supplement to the method described in Chinese Pharmacopeia.
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Hyperspectral Imaging , Least-Squares Analysis , Plant Roots , SulfurABSTRACT
Objective To determine the relationship between air pollutants [SO
Subject(s)
Female , Humans , Male , Acne Vulgaris , Air Pollution/adverse effects , China/epidemiology , Environmental Pollutants , Gases , OutpatientsABSTRACT
BACKGROUND@#Children in Ulaanbaatar are exposed to air pollution, but few epidemiological studies have been conducted on the effects of environmental risk factors on children's health. Also, no studies have yet examined the prevalence of respiratory symptoms in children in suburban areas, where air quality-monitoring stations have not yet been installed. This cross-sectional study evaluated the associations between outdoor air pollution and respiratory symptoms among schoolchildren in urban and suburban districts of Ulaanbaatar.@*METHODS@#The ATS-DLD-78 C questionnaire was used to investigate the respiratory symptoms of schoolchildren aged 6-12 years (n = 1190) who lived in one of three urban districts or a suburban district of Ulaanbaatar. In each district, the outdoor concentrations of nitrogen dioxide (NO) and sulfur dioxide (SO) were measured at two sites (at ≤100 m and > 100 m from the nearest major road) in the 2-year period from 2015 to 2016. The associations between health outcomes and exposure to air pollutants were estimated using the multinomial logistic regression method.@*RESULTS@#The outdoor concentration of SO was significantly associated with persistent cough symptom (OR = 1.12, 95% CI 1.04-1.22). Furthermore, the outdoor concentration of NO was significantly associated with the current wheezing symptom (OR = 1.33, 95% CI 1.01-1.75) among children in urban and suburban.@*CONCLUSIONS@#The prevalence of persistent cough symptom was markedly high among the schoolchildren in urban/suburban districts of Ulaanbaatar. Overall, the increases in the prevalence of respiratory symptoms among children might be associated with ambient air pollution in Ulaanbaatar.
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Objective To study the effects of air pollution including sulphur dioxide (SO2),nitrogen dioxide (NO2) and PM10 in Xi'an on birth defects.Methods We collected the birth defects data from Xi'an Maternal and Child Health Hospital,meteorological data from Xi'an Bureau of Meteorology,and the air pollution data from Xi'an Environment Monitoring Station from 2010 to 2015.Generalized additive model (GAM) was used to explore the relationship between air pollution and birth defects after adjusting the effects of long-term and seasonal trend,temperature,and relative humidity.Results The monthly average birth defects were 89 cases;the monthly average concentration of SO2,NO2 and PM10 was 34.05 μg/m3,45.13 μg/m3,and 96.77 μg/m3,respectively.In the GAM,the monthly average temperature was 13.57 ℃ and the relative humidity was 63.20％.The three kinds of air pollutants all had a certain lag effect in 10 months,which reached the maximum.With an increase of concentration by 10 μg/m3 in three air pollutants,the relative risks and confidence interval of SO2,NO2,and PM10 were 1.060 (1.023-1.097),1.033 (1.014-1.052) and 1.018 (1.007-1.029),with significant differences (P＜0.05).Conclusion Exposure to SO2,NO2,and PM10 may be associated with the risk of birth defects.
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Objective Previous studies found that characteristic sulfur-containing derivatives induced by sulfur-fumigation of medicinal herbs could be used together with sulfur dioxide (SO2) as chemical markers for the quality control of sulfur-fumigated herbs owing to the more specific and reproducibility of characteristic sulfur-containing derivatives over SO2 index. In this paper, the feasibility of these two indices used for the quality control of herbal dispensing granules was further investigated. Methods Using Paeoniae Radix Alba (PRA) as an example, the contents of SO2, paeoniflorin as well as paeoniflorin sulfonate, the characteristic sulfur-containing derivatives of sulfur-fumigated RPA in PRA processing pieces, decoctions, concentrates, and dried extracts were quantified by SO2 residue determination method documented in Chinese Pharmacopeia and HPLC technique, and the transfer ratios of these components during preparation procedures of PRA dispensing granules were evaluated. Results It was found that SO2, paeoniflorin and paeoniflorin sulfonate could all be detectable in the samples of decoctions, concentrates and dried extracts, indicating that these three components could be used as chemical markers to indicate the quality changes during preparation of PRA dispensing granules. However, the transfer ratios of these three components were different from each other, with the contents of SO2 and paeoniflorin decreased, whereas that of paeoniflorin sulfonate increased during preparation of PRA dispensing granules. In addition, in those commercial PRA dispensing granules samples SO2 detectable, paeoniflorin sulfonate also detectable. Conclusion Since SO2 residue is a safety index, while paeoniflorin and paeoniflorin sulfonate can reflect the inner quality and the impact extent of sulfur-fumigation on the quality of PRA dispensing granules respectively, the three components might be used together as chemical markers for the quality control, and consequently to ensure the safety and efficacy of PRA dispensing granules.
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Objective To assess the level of sulfur dioxide(SO2) residues in sea shrimps on the market and to evaluate the health risk of the SO2 exposure of Wenzhou population by eating sea shrimp .Method SO2 residues in 246 sea shrimp samples collected from Wenzhou market from 2015 to 2016 were analyzed. The point assessment method was used to evaluate the risk of SO2 exposure for consumers,using the data of residents' consumption survey in 2008 in Zhejiang Province.Results The median of SO2 residual in the whole shrimp and the shrimp without shell were 20.05 mg/kg and 10.65 mg/kg respectively(P<0.05). The over-standard rate of SO2 for the whole shrimp and the shrimp without shell were 19.11% and 5.69%(P<0.05) respectively. The average exposure of SO2 in general population by eating the whole shrimp and the shrimp without shell were 0.0459 mg/kg BW and 0.0076 mg/kg BW respectively. However,the exposure of SO2 in high-consuming population (>P97.5) by eating the whole shrimp and the shrimp without shell were 0.1142 mg/kg BW and 0.0189 mg/kg BW respectively. The exposure level of SO2 in men were lower than in women. Conclusion The health risk of the SO2 exposure by eating sea shrimp in general population and high-consuming population is in a low level in Wenzhou.
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BACKGROUNDAir pollution issue has become the largest problem of Ulaanbaatar city in the last decade affecting health and wellbeing of its citizens. Air pollution levels are increasing considerably in winter as a result of coal burning by city dwellers living in ger areas. Our study purpose was to survey the impact of air pollution on infant health of Ulaanbaatar city in 2012.METHODSData of 7484 on births at Khan-Uul and Sukhbaatar districts residence mothers and infants of Ulaanbaatar city from 2012 and corresponding daily air pollution level data (CO, NO2, SO2 and PM10) from the Ulaanbaatar city air quality monitoring stations were used.RESULTSAir pollution levels in Ulaanbaatar city significantly affect birth outcomes. Exposure to high levels of СО2 of during the third trimester of pregnancy reduces newborn’s weight. Exposure to NO2 is not influencing to newborn’s weight. Mothers who lived in more polluted area during pregnancy period more likely had baby reduced weight in 44 grams.
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Simultaneous removal of NOx and SO2 from exhausted gas were investigated by studying co-culture of sulfate reducing bacteria and anaerobic denitrifying bacteria, separated from landfill leachate. When H2S, generated by sulfate reducing bacteria was chosen as the sole electron donor for anaerobic denitrifying bacteria, the co-culture system demonstrated a faster NO removal rate, higher stability and better permanence. When the feed gas flow rates of N2 and SO2 were maintained constant at 0.1 m3/h and 16 ml/min respectively, the maximum NO-removal rate could be achieved at over 92% with NO feed gas kept between 2-6 ml/min, while the SO2 removal rate was always above 95%. Long-term continuous removal of NO exhibited an evident periodicity of five days, however, the fluctuation range of NO-removal was decreasing. Moreover, the decrease of the gas flow rate and the increase in NO inlet concentration could contribute to a higher NO-removal rate.
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The experiments of this study was performed to investigate the effects of sulfur dioxide on the changes of glycoconjugates of respiratory system of the rat. Sprague -Dawley male rats weighing about 200 ~250g were divided into a control group and SO2 exposed groups. Again SO2 exposed groups were divided into 10 ppm, 25 ppm, 50 ppm, 100 ppm and 200 ppm subgroups according to concentrations of SO2 and each SO2 exposed groups were divided into 1, 3 and 6 hours groups. For the histological changes, H -E(hematoxylin -eosin) and PAS(periodic acid Schiff) staining were used and to investigate the change of sugar residues of glycoconjugates, biotinylated lectins(DBA, SBA, PNA, BSL -1, sWGA, UEA -1, LCA and Con A) were applied. Generally, the effects of SO2 on the rat nasal respiratory region were more serious at the high concentrations. Moreover, as the exposed time was longer even at the low concentrations, the effects of SO2 were similar to those of high concentration. Compared with all SO2 concentrations, the longer exposed time was, the more serious the effects of SO2 were. In the SO2 exposed groups the binding of PNA, RCA -1 and UEA -1 of cilia in the nasal septal respiratory epithelium tended to increase in the 10 ppm and 25 ppm SO2 exposed groups but it tended to decrease in the 100 ppm and 200 ppm SO2 exposed groups. In the cytoplasm of columnar cells of nasal septal respiratory epithelium, Con A binding increased in all the SO2 exposed groups. In the goblet cells DBA, SBA, PNA, RCA -1 and UEA -1 binding increased remarkably in the 50 ppm SO2 exposed groups but it decreased largely or disappeared in the 100 ppm and 200 ppm SO2 exposed groups. The binding of SBA, PNA, BSL -1, UEA -1 and Con A in the intraepithelial mucous cells which were not detected in the control group, increased in the 25 ppm and 50 ppm SO2 exposed groups while it tended to decrease in the 100 ppm and 200 ppm SO2 exposed groups. The binding of sWGA increased according to the concentrations of SO2 were higher and exposed times were longer. In the superior nasal septal gland, the binding of PNA increased in the 50 ppm and 100 ppm SO2 exposed groups and that of Con A increased in the 25 ppm and 50 ppm SO2 exposed groups. In the inferior nasal septal gland, except for LCA, the binding of the other lectins increased remarkably in the 25 ppm and 50 ppm SO2 exposed groups but it tended to decrease in the 100 ppm and 200 ppm SO2 groups. In the mucous duct cells, the reaction of PNA and RCA -1 increased compared with that of the control group. And the reaction of BSL -1 and UEA -1 increased in the lower concentrations of 50 ppm SO2 exposed group but it decreased in the 100 ppm and 200 ppm SO2 exposed groups. The binding of Con A increased in the 25 ppm and 50 ppm SO2 exposed groups. Consequently, from the results above mentioned that SO2 affected serious changes on glycoconjugates metabolism in the nasal cavity.
Subject(s)
Animals , Humans , Male , Rats , Cilia , Cytoplasm , Glycoconjugates , Goblet Cells , Lectins , Metabolism , Nasal Cavity , Respiratory Mucosa , Respiratory System , Sulfur DioxideABSTRACT
BACKGROUND: Despite the evident age differences in the risk of asthma attack due to air pollution, most studies have recruited subjects from all age groups. Although this effort might be feasible for maintaining statistical power, it biases the effect estimate towards the null among children who are more sensitive to air pollution than adults. OBJECTIVES: To estimate the risk of air pollution on children living in Seoul who have made doctor visits for asthma. METHOD: From 1992 to 1993, daily number of doctor visits due to asthma attack was tallied among children between 4 and 11 years old living in Seoul from the insurance claim forms of Korean Medical Insurance Corporation (KMIC). 24-hour mean concentrations were calculated for TSP, SO2, O3 and NO2 based on hourly concentrations measured at 20 monitoring stations. To estimate the effect of TSP or SO2 on asthma attack, a Poisson regression model was used with adjustments for long-term trend, seasonal variation, day-of-week effect, and meteorological factors such as temperature, humidity, wind velocity and duration of sunshine. To prevent autocorrelation, autoregressive error terms were tried with different lag periods. RESULTS: The cumulative effect of a current day and previous five days turned out to be stronger than that of any single day. These relationships were observed more clearly after the effects of O3 and NO2 were controlled. For 100microgram/m3 increase of cumulative concentration of TSP, the relative risk was 1.27 (95% CI: 1.08, 1.49); for 50ppb increase of cumulative concentration of SO2, the relative risk was 1.56 (95% CI: 1.29, 1.89). After the effects of O3 and NO2 were removed in a multiple regression model, it increased to 1.37 (95% CI: 1.10, 1.69) and 1.66 ((%% CI: 1.34, 2.07), respectively. CONCLUSION: The concentrations of TSP and SO2 turned out to be significantly associatedwith asthma attack among children. As expected, the risk estimates were larger than those of previous studies which recruited subjects from all age groups, or used mortality or hospitalization as their outcome.
Subject(s)
Adult , Child , Humans , Air Pollution , Asthma , Bias , Hospitalization , Humidity , Insurance , Meteorological Concepts , Mortality , Seasons , Seoul , Sunlight , WindABSTRACT
This experiment was performed the effect of the glycoconjugates of the skin in the Sprague-Dawley male rats exposed to SO2 for 1, 3 and 6 hours with various concentrations (10, 25, 50, 100 and 200 ppm). To investigate the change of glycoconjugates of skin, seven biotinylated lectins (DBA, SBA, PNA, BSL-1, sWGA, UEA-1, Con A) were applied with ABC method. The epidermis of experiment rats was more or less different according to the concentration of SO2, comparing control group, and beta-N-acetyl-D-galactosamine, alpha-L-fucose, alpha-D-mannose and alpha-D-glucose of the epidermis tend to be increased according to exposed SO2 time, but alpha-D-galactose was tend to be decreased. Galactose-beta-1, 3-Nacetyl- D-galactosamine was tend to more or less increase in horny layer of the epidermis, but decrease in granular and spinous layers. As contrasted control group, beta-N-acetyl-D-glucosamine in the dermis of experiment rats was decreased, but alpha- D-mannose and alpha-D-glucose were increased. In the hair follicle of the experiment rats, beta-N-acetyl-D-galactosamine and galactose-beta-1, 3-N-acetyl-Dgalactosamine tend to be decreased according to exposed SO2 time though more or less differ from the portions of the hair follicle, and beta-N-acetyl-D-glucosamine and alpha-L-fucose were found noticeably to increase comaring control group. According to exposed SO2 time, the decrease of alpha-D-galactose tend to be little more pronounced in the outer root sheath of the upper portion of hair follicle. In contrast, the same sheath of the upper portion in above follicle was increased relatively. alpha-D-mannose and alpha-D-glucose were increased in the root sheath of hair follicle and hair cortex, but decreased in the hair medulla. In the experiment rats, the beta-N-acetyl-D-galactosamine tend to be decreased gradually according to exposed SO2 time, but the decrease of galactose-beta-1, 3-N-acetyl-D-galactosamine were showed significantly as contrasted control group. beta-N-acetyl-D-glucosamine, alpha-D-mannose and alpha-D-glucose were increased gradually according to exposed SO2 time, but alpha-L-fucose was increased remarkably. The effect on lectin binding pattern of the glycoconjugates in the rat skin according to the concentrations and exposed time of SO2 was noted that the alternations of lectin binding pattern tend to be a little more pronounced in low concentration of exposed SO2 for a long time than in high concentration of exposed SO2 for a short time. The alternations of lectin binding pattern were appeared almost similar in concentrations of 50 ppm SO2 and above.
Subject(s)
Animals , Humans , Male , Rats , Dermis , Epidermis , Glycoconjugates , Hair , Hair Follicle , Lectins , Mannose , Rats, Sprague-Dawley , Skin , Sulfur Dioxide , SulfurABSTRACT
Objective To study lexicological effects of sulfur dioxide (SO2) on reproductive system of male mammals. Methods After dynamic 7-day inhalation of SO2 at various concentrations, such as (22